Reoxygenated effluent of Tyrode-perfused heart affects papillary muscle contraction independent of cardiac perfusion

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Reoxygenated effluent of Tyrode-perfused heart affects papillary muscle contraction independent of cardiac perfusion.

OBJECTIVE We determined, via a bioassay, if inotropic factors are released in the coronary circulation of the rat heart and if changes in cardiac perfusion change papillary muscle inotropy. METHODS An isolated isometrically contracting rat papillary muscle (n = 5, acceptor) was superfused with Tyrode or with reoxygenated coronary venous effluent from an isolated isovolumically beating rat hea...

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Identification of Two Main Independent Components of Fibrillating Heart Muscle

Fibrillation is a hazardous phenomenon in cardiac muscle and so any new work towards the understanding of this process is important to the development of new methods in diagnosis and therapy. In this work we have used surface and intra cardiac ECGs of patients with chronic atrial fibrillation (AF). By means of the blind source separation (BSS) algorithm, which is a well-known method in signal p...

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Endothelial cells regulate cardiac contractility.

Endothelial cells lining the lumen of blood vessels contain the receptors for many substances that alter the contractile tone of smooth muscle in the walls of the blood vessels. In response to their interaction with the signal substances, the endothelial cells release vasoactive factors that modify the contractile state of the vascular smooth muscle. This study was conducted to determine if end...

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identification of two main independent components of fibrillating heart muscle

fibrillation is a hazardous phenomenon in cardiac muscle and so any new work towards the understanding of this process is important to the development of new methods in diagnosis and therapy. in this work we have used surface and intra cardiac ecgs of patients with chronic atrial fibrillation (af). by means of the blind source separation (bss) algorithm, which is a well-known method in signal p...

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Cold acclimation of guinea pig depressed contraction of cardiac papillary muscle.

Guinea pigs were exposed to 5 degrees C for 3 wk, and the contractions of myocardial papillary muscle were compared with preparations dissected from control animals kept at approximately 25 degrees C. Developed tension of the papillary muscle per cross-sectional area was significantly (t-test, P < 0.05) decreased after cold exposure (19,200 +/- 8,160 vs. 3,020 +/- 2,890 dyne/cm2; 1 Hz). Time to...

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 1997

ISSN: 0008-6363

DOI: 10.1016/s0008-6363(96)00173-3